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Nicotine, most likely via 7 and 42 nAChRs, may cause alterations in molecular and cellular processes, hence modulating disease in synaptic plasticity [67] Rodent model observations reveal sustained after being exposed to nicotine during embryonic development, there are increases in nicotine binding, and it seems that 42 * the more nAChRs susceptible 7 nAChRs increase regulation [67, 68]

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Lancet Neurol 23(7):712724 Ferrari A, Zappaterra M, Righi F, Ciccarese M, Tiraferri I, Pini LA et al (2013) Impact of continuing or quitting smoking on episodic cluster headache: a pilot survey

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