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Additionally, it has been reported that nicotine metabolism is impaired and even reduced by tobacco smoke through the inhibition of CYP2A6, which is mainly responsible for the conversion to cotinine (Lee et al., 1987

In this case, ongoing awareness of jaw pain from gum chewing can act as a springboard for pain pathways that gradually become more sensitized, a process described as pain amplification and identified as a risk factor for TMD in research from the OPPERA (Orofacial Pain Prospective Evaluation and Risk Assessment) initiative

But discussions around exactly how harmful e-cigarettes could be to users and those within close proximity, are still ongoing

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However, extending the course for 12-18 months may help reduce relapse