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While it is unclear whether CS alters Treg numbers and function in the context of transplantation, previous studies have revealed a significant downregulation of CD4+ CD25+ Treg cell numbers in bronchoalveolar lavage fluid and blood of smoking patients with COPD compared with healthy non-smokers ( Memory T Cells Memory T cells can rapidly initiate alloimmune responses through the production of pro-inflammatory or effector cytokines ( Memory B Cells It is well accepted that both memory T and memory B cells prevent the long-term survival of transplanted organs and hinder the induction of transplant tolerance