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The best option is to never smoke or quit smoking if you have already started

These distinct mutational patterns likely reflect differences in toxicokinetics, the nature of DNA damage induced, and the repair mechanisms involvedparticularly the predominant use of error-prone NHEJ in response to radon-induced DSBs, which promotes deletions and chromosomal rearrangements, while tobacco-related damage more often leads to a mutation landscape dominated by SNVs and transversions due to DNA adducts and oxidative stress (97)

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