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Experimental evidence demonstrates that mast cellderived mediators can directly act on receptors of sensory neurons, enhancing the sensitivity of peripheral nerve endings to inflammatory signals and thereby sustaining the persistent transmission of itch (50, 51).Conversely, sensory neurons, upon activation, release neuropeptides such as SP and CGRP, which act directly on vascular smooth muscle cells and endothelial cells to induce neurogenic vasodilation and plasma extravasation (52, 53)
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