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Due to the downregulation of colonic CD4 T cell nAChRs controlled by IL-12, nicotine aggravated colonic inflammation with the development of wide-ranging mucosal cell death in the proximal colon, exhaustive crypt injury, entire goblet cell exhaustion, lamina propria ruination, and huge lymphocytic infiltration [62]
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![Fig. 6.1.1, [The MPOWER measures, established by WHO to help reduce demand for tobacco.]. - World Cancer Report](https://www.ncbi.nlm.nih.gov/books/NBK606526/bin/978-92-832-0448-0-C-F6.1.1.jpg)
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