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The sample recruited in our VBM study was also small ( Additionally, scholars have recently proposed that the persistence of drug use despite adverse consequences (and that according to our theoretical paradigm may be associated with a decrease in interoceptive awareness) is not a unitary construct and may encompass three dissociable cognitive, motivational, and behavioral pathways (61)

It also affects reward pathways in the brain, which may be relevant for behaviours like smoking

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