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Extraction of impacted third molars (wisdom teeth) can be traumatic, as some surrounding gum tissue and jawbone may need to be removed or may be adversely affected during surgery

Co-administration with other drugs that are metabolized by CYP 3A4 (e.g., ) may increase their clearance, resulting in decreased plasma concentration

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Infants who die from Sudden Infant Death Syndrome tend to have higher concentrations of nicotine and cotinine (a biological marker for secondhand smoke exposure) in their lungs than those who die from other causes