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4 Effects on Organ Systems Cardiovascular System Nicotines effects on peripheral chemoreceptors include increased adrenaline secretion from the adrenal medulla, direct stimulation of the carotid and aortic bodies, and increased sympathetic tone from the autonomic ganglia

As Ive found when reading journals from the early 1900s at the British Library, smoking was seen by some doctors and anti-tobacco activists to cause bad manners and antisocial behaviour in idle young boys

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But with blunts, thats exactly what most users do