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Regarding glutamatergic neurotransmission, activation of CB 1 receptors by anandamide and synthetic cannabinoids WIN 55212-2 and CP55940 increase glutamatergic signaling to the PVN and ARC by activating NMDA receptors in locus coeruleus ( locus coeruleus has innervations to the PVN and ARC in the hypothalamus ( locus coeruleus activity were to occur, it could result in NA release and activation of parvocellular neurons in the PVN through 1 -adrenoreceptors

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