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Seneca brand background Grand River Enterprises launched Seneca cigarettes, which operate under Native American tribal sovereignty on reservation lands

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In the CNS, endocannabinoids mediate retrograde signaling that begins with the synthesis of 2-AG or AEA in the postsynaptic membrane

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Other ancient Chinese texts describe cannabis as a hallucinogen in the context of shamanism, which was widespread in regions of Central and Western Asia, as well as India, leading to an increase in cannabis use in those regions [13]