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The film stars an ensemble cast which includes James Gandolfini, Susan Sarandon, Kate Winslet, Steve Buscemi, Bobby Cannavale, Mandy Moore, Mary-Louise Parker, Aida Turturro, Christopher Walken, Barbara Sukowa, Elaine Stritch, Eddie Izzard, and Amy Sedaris

Further, epigenetic testing in brains recovered postmortem from offspring showed increased DNA methylation, and alteration of 13-genes involved in neurological activity [98]

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