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However, it was not known whether this duration of time was sufficient for protease activity to return to baseline for every participant, and it is possible that baseline protease levels could have been influenced by prior exposures
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In the pioneering studies by Sleiman et al., the major TSNA formed from the reaction of nicotine with nitrous acid, under conditions that modeled indoor environments, was 4-methylnitrosamino-4-(3-pyridyl)-butanal (NNA), as discussed above 5 (Scheme 1)
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