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Airway epithelial barrier dysfunction not only impairs the physical barrier activity of airway epithelium, but further exposes sub-epithelial layers to exogenous substances, leading to a series of pathological processes such as airway inflammation, airway remodeling, airway hyperresponsiveness and increasing the rate of COPD exacerbation [7, 8]

These numbers represent one of the biggest challenges of clinical trials, especially in the field of risky behaviors like smoking

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These explosions can also take place with non-defective batteries if they get damaged