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When you try to quit, your body goes through withdrawal and you may experience negative symptoms like irritability , anxiety , and trouble sleeping
Cardiovascular System Smoking causes the blood vessels to tighten, which restricts the flow of blood
Nicotine has also been reported to induce UGT1A1 in HIV-infected patients and thus could directly affect the metabolism of abacavir, raltegravir, and elvitegravir that use similar enzyme metabolism systems (Parant et al., 2019)
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These elements, which act through pathways other than nAChRs, warrant additional study
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