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In their reporting on a 2025 study from the Journal of the American College of Cardiology (JACC), Medscape summed up, Compared with people who said they did not use cannabis, those who reported using the drug had a sixfold increased risk for heart attack, a fourfold increased risk for ischemic stroke, double the risk for heart failure, and three times the risk for cardiovascular death, heart attack, or stroke [10]