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Nicotine pouches have relatively less regulatory pushback due to them being smoke-free

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(2009) in The Neurobiology of Anxiety Disorders: Brain Imaging, Genetics, and Psychoneuroendocrinology indicates that patients with anxiety disorders exhibit increased glutamate activity, which is associated with symptom severity

3.2.5 The gateway effect A growing body of longitudinal evidence supports the gateway effect, in which adolescent e-cigarette use increases the likelihood of later use of traditional cigarettes and other addictive substances

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