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The World Health Organization reports that tobacco kills more than 8 million people each year, that 80% of the world's tobacco users live in low- and middle-income countries, and that in 2020 22.3% of the world's population used tobacco, including 36.7% of all men and 7.8% of the world's women

45,46 TAMs compose 50% of the total cell population in situ 47 and are primarily derived from cytokine-recruited macrophages that are secreted by TME stromal cells and cancer cells, and include CCL2, CCL5, and CSF1

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Available at: [Accessed 23 August 2018] [72] Elkin L, Thomson G, Wilson N